TriBute Vet Reference Extract

EquiNatural® | 4-in-1 Botanical Nutritional Support for Equine Foregut Comfort & Mucosal Resilience

Organically grown • Human grade • Not veterinary medicine


1. Important Context for Veterinary Review

Equine gastric ulcer syndrome (EGUS) reflects a complex interplay of:

  • feeding intervals and forage scarcity
  • acid splash exposure
  • stress physiology and cortisol load
  • compromised mucosal defence
  • pain-linked sympathetic activation
  • training intensity and management conditions
  • underlying biome and autonomic imbalance


Squamous and glandular/pyloric ulcers differ in aetiology and healing behaviour, but both represent multifactorial digestive–stress interactions rather than a single causative factor.


UlsaCOMBO is a nutritional support programme, not a replacement for veterinary diagnosis, gastroscopy, or medical therapy. It should be introduced with ongoing veterinary oversight in horses with confirmed or suspected EGUS, especially when transitioning off omeprazole or sucralfate.


2. Product Summary

UlsaCOMBO combines four EquiNatural blends — DuoBute, StressTonic, UlsaTonic, and GutAminos — into a single, structured 4-in-1 nutritional programme aimed at supporting:

  • foregut comfort
  • mucosal resilience
  • inflammatory balance
  • digestive tension
  • stress-related gastric sensitivity
  • post-omeprazole stabilisation


It offers soothing, buffering, calming, and tissue-supportive nutrition to complement management strategies while supporting the gut–nerve axis.


Not intended as a medical ulcer treatment.


3. Clinical Rationale (Nutritional Mechanisms of Action)

EGUS arises when the protective mechanisms of the stomach (mucus, bicarbonate, epithelial blood flow, mucosal turnover) are outpaced by:

  • persistent acid exposure
  • stress-induced sympathetic activation
  • decreased mucosal perfusion
  • reduced prostaglandin-mediated protection
  • biome disruption and delayed gastric emptying


UlsaCOMBO’s combined botanicals have been traditionally used to support:


Acute Comfort & Inflammatory Balance

(Meadowsweet, Willow, Devil’s Claw)

  • natural salicylates support prostaglandin pathways
  • soothe acute tension and tissue sensitivity


Stress Physiology & Vagal Tone

(Withania, Passiflora, Melissa, Eleutherococcus)

  • modulate sympathetic overactivation
  • help maintain a calmer digestive–neuro axis


Mucosal Defence & Cytoprotection

(Symphytum, Althaea, Mentha, Hydrocotyle)

  • support epithelial integrity
  • provide mucilage and soothing polyphenols
  • encourage healthy gastric surface renewal


Hepatic–Metabolic Stability & Circulatory Support

(Nettle, Hawthorn, Ginkgo, Olea europaea)

  • maintain healthy microcirculation
  • support detox pathways linked to systemic stress


Amino Acid Repair Substrates

(N-Acetyl L-Cysteine, L-Glutamine)

  • nutritional support for epithelial turnover
  • glutamine as a substrate for enterocyte regeneration
  • NAC supporting antioxidant and mucosal stability


This multi-angle nutritional approach aligns UlsaCOMBO with Cleanse → Activate → Regenerate phases of EquiNatural’s C.A.R.E. Protocol, supporting both comfort and long-term mucosal steadiness.


4. Nutritional Indications (Non-Diagnostic)

UlsaCOMBO may be considered as nutritional support for horses experiencing:

  • foregut sensitivity, girthiness, and tension
  • stress-linked digestive reactivity
  • behaviours associated with gastric discomfort
  • post-omeprazole transitions requiring mucosal nutrition
  • squamous irritation patterns from management gaps
  • glandular/pyloric sensitivity linked to stress and cortisol
  • digestive tension during travel, stabling, or training load


Not intended to diagnose, treat, or resolve EGUS.


5. Composition (Organically Grown, No Ratios Listed)

Botanical Safety Preface

Botanicals provide nutritional support, not medicinal treatment. Individual responses vary based on forage access, diet, stress load, biome health, and underlying conditions. The following monographs represent traditional and nutritional uses.


Herbs Included

From DuoBute (Comfort Support):

  • Filipendula ulmaria (Meadowsweet)
  • Salix alba (Willow Bark)


From StressTonic (Gut–Nerve Support):

  • Withania somnifera
  • Matricaria recutita
  • Eleutherococcus senticosus
  • Ginkgo biloba
  • Hydrocotyle asiatica
  • Melissa officinalis
  • Glycyrrhiza glabra
  • Urtica dioica Folia
  • Passiflora incarnata
  • Verbena officinalis


From UlsaTonic (Mucosal Support):

  • Symphytum officinale Folia
  • Althaea officinalis Radix
  • Mentha piperita
  • Olea europaea


From GutAminos (Amino Acid Support):

  • N-Acetyl L-Cysteine
  • L-Glutamine


6. Micro-Monographs (Selected Highlights)

Meadowsweet & Willow
Provide natural salicylates supporting normal inflammatory balance and systemic comfort, while Meadowsweet’s mucilage supports gastric calm.


Withania, Passiflora, Melissa
Support normal cortisol cycling, vagal tone, and gut–nerve equilibrium in stress-linked gastric sensitivity.


Symphytum & Althaea (Mucilaginous Botanicals)
Rich in soothing compounds traditionally used to support epithelial integrity and gastric surface comfort.


Glycyrrhiza glabra (Liquorice Root)
Supports mucosal resilience but may influence cortisol clearance — requires steroid caution.


NAC & L-Glutamine
Provide key nutritional substrates for epithelial turnover, gastric lining maintenance, and antioxidant stability.


7. Medication Considerations

Veterinary supervision is recommended when feeding UlsaCOMBO alongside:

  • Steroids (prednisolone, dexamethasone, inhaled steroids)
    Liquorice Root may prolong steroid activity.
  • Anticoagulants / blood thinners
    Willow and Meadowsweet contain natural salicylates.
  • Sedatives or CNS-acting medications
    Passiflora and Melissa may contribute mild calming effects.
  • Drugs affecting renal or hepatic processing
    Liquorice and Nettle influence fluid and electrolyte handling.
  • Competition horses
    FEI-controlled: Devil’s Claw, salicylates, Passiflora.
  • Omeprazole, sucralfate, or antacids
    Allow 2–3 hours spacing to avoid interference with absorption or mucilage binding.


No known pharmacodynamic interactions documented at nutritional levels, but caution is required for the above categories.


8. Feeding Guidance

Combined Blend (Herbal + Amino Acids):
15g per 100kg bodyweight daily
(75g for a 500kg horse)
1 x level 75ml scoop ≈ 18g.

Introduce gradually over 5–7 days.


If unexpected sensitivity occurs, discontinue and consult a veterinarian.


9. Clinical Considerations

Advisories

  • Formulated for horses showing significant gastric sensitivity or stress-linked foregut patterns.
  • Introduce slowly to allow digestive accommodation.
  • Provide constant forage to maintain natural buffering.
  • Suitable long-term when fed at recommended levels.
  • Separate from omeprazole/sucralfate by several hours.


Contraindications

  • Pregnancy or lactation (adaptogens + Passiflora + Liquorice).
  • Horses on steroids or immunosuppressants (Liquorice caution).
  • Horses on anticoagulants (Willow + Meadowsweet salicylates).
  • Horses with fluid retention or hepatic compromise.
  • Competition horses under FEI rules.


10. Supporting Products (Nutritional Context)

  • LeakyGutCOMBO — biome stabilisation post-ulcer support
  • StressTonic — vagal tone and nervous system steadiness
  • MagCARE — tension and metabolic muscle support
  • EquiVita / VitaComplete — forage-balancing mineral nutrition
  • BiomeTonic — intestinal terrain stability


11. Standard Nutritional Disclaimer

UlsaCOMBO is produced from organically grown botanicals and provided as a nutritional, functional food supplement. It is not veterinary medicine and does not diagnose, treat, cure, or prevent disease. Veterinary oversight is essential for horses with gastric ulcers, foregut disease, or receiving concurrent medication.