DuoBute Veterinary Reference Extract

EquiNatural® | Botanical Nutritional Support for Chronic Discomfort, Inflammatory Balance & Long-Term Mobility

Organically grown • Human grade • Not veterinary medicine

1. Important Context for Veterinary Review

Chronic low-grade inflammation in horses is rarely isolated — it reflects a mixture of:

  • joint and connective tissue wear
  • mechanical strain
  • metabolic load (especially EMS-associated hoof inflammation)
  • gut–immune interactions
  • age-related microvascular changes


Pharmaceutical NSAIDs (phenylbutazone, meloxicam) remain essential in acute care but are limited by:

  • GI mucosal irritation
  • renal stress under dehydration
  • hepatic workload
  • rebound inflammatory sensitivity after withdrawal


DuoBute is positioned as a long-term nutritional alternative, providing steady comfort support through natural salicylates (Meadowsweet + Willow) and mucosal-buffering compounds that moderate rather than suppress inflammatory activity. It is not a treatment for acute pain, laminitic crisis, infection, or structural joint disease — veterinary assessment remains essential in these cases.


Functional Positioning — DuoBute

DuoBute is intended for the maintenance phase of comfort support, offering gentle, daily modulation of inflammatory pathways in horses living with chronic stiffness, joint wear, or systemic low-grade inflammation.


Where NSAIDs act by blocking COX pathways, DuoBute uses phyto-salicylates + mucosal protectants to support comfort while maintaining biochemical signalling necessary for tissue repair and long-term joint adaptation.


It is designed for:

  • ongoing daily comfort
  • horses transitioning off pharmaceutical NSAIDs
  • ageing or arthritic horses needing sustainable support
  • metabolic horses with low-grade hoof inflammation
  • post-rehab or long-term maintenance programmes


It is not designed for:

  • acute flare-ups → TriBute
  • laminitic emergencies → veterinary acute protocol
  • gastric-ulcer cases needing demulcent-first intervention


Core Actions

  • Modulates natural inflammatory pathways through salicylate-rich botanicals
  • Supports joint and connective tissue comfort during chronic wear and stiffness
  • Provides gastric buffering to protect mucosa during long-term use
  • Supports circulatory flow to tissues under chronic strain
  • Promotes steadier mobility without sedation or suppression


Rationale for Key Components

Filipendula ulmaria (Meadowsweet)

  • Natural salicylates supporting prostaglandin modulation
  • Dual function: comfort support + gastric mucosal protection
  • Traditionally used to soothe GI terrain during inflammatory states

Salix alba (Willow Bark)

  • Source of salicin and related salicylates
  • Long-recognised botanical for managing chronic inflammatory discomfort
  • Supports joint flexibility and daily mobility

The Meadowsweet–Willow pairing reflects a traditional synergy: comfort + digestion.


2. Product Summary

DuoBute is a gentle, long-term nutritional comfort formula formulated around two key phyto-salicylate herbs. It aides natural inflammatory steadiness, mobility, and tissue comfort for horses living with chronic stiffness, low-grade inflammation, or age-related joint change.


3. Clinical Rationale (Nutritional Mechanisms of Action)

Phyto-Salicylate Modulation

(Meadowsweet + Willow)

  • Supports prostaglandin balance without NSAID-style suppression
  • Avoids abrupt COX inhibition, reducing risk of rebound sensitivity

Gastroprotective Influence

(Meadowsweet)

  • Provides protective tannins and mucilage-like compounds
  • Supports gastric lining integrity when long-term comfort support is needed

Oxidative Stress Moderation

  • Natural polyphenols reduce oxidative load in tissues chronically under strain

Microvascular Support

  • Long-term comfort relies on healthy microcirculation to joints, hooves, fascia

Nutritional salicylates are not pharmaceutical NSAIDs; their action is modulatory and gentle.


4. Nutritional Indications (Non-Diagnostic)

DuoBute may be considered for horses showing:

  • chronic stiffness or joint wear
  • age-related mobility limitations
  • long-term inflammatory tension
  • low-grade hoof inflammation associated with metabolic stress
  • post-injury maintenance after acute recovery phase
  • sensitivity when withdrawing from bute

Not indicated for:

  • acute laminitis
  • fever or infection
  • acute mechanical injury or fracture
  • uncontrolled metabolic crisis


5. Composition

Botanical Ingredients:

  • Filipendula ulmaria (Meadowsweet)
  • Salix alba (Willow Bark)

Organically grown • Human grade • Ecological standards
No fillers, synthetics, or additives


6. Herb Micro-Monographs (Technical)

Filipendula ulmaria

  • Natural salicylates for gentle inflammatory support
  • Tannins + polyphenols offer GI mucosal protection
  • Traditional use in digestive and joint comfort applications

Salix alba

  • Salicin metabolised to salicylic derivatives
  • Phytochemical profile supports long-term comfort
  • Historically used for musculoskeletal ease


7. Medication Considerations

Use under veterinary guidance when the horse is receiving:

  • Anticoagulants → salicylates may influence clotting time
  • NSAIDs → overlapping salicylates may potentiate effect
  • Steroid medications → not contraindicated but inflammatory picture should be professionally monitored
  • Gastric ulcer treatment → Meadowsweet offers some support, but GI-first formulas preferred


Competition:
Contains natural salicylic acid — controlled substance under FEI rules.
Owners must check current regulations.


8. Feeding Guidance

Dried Herb Blend

  • 5 g / 100 kg bodyweight daily (25 g for a 500 kg horse)
  • 1 level 75 ml scoop ≈ 12 g

Tincture Option

  • 6 ml / 100 kg bodyweight (30 ml for a 500 kg horse)

Introduction:
Introduce gradually over 3–5 days.

Sensitivity Advisory:
Discontinue if unexpected digestive or behavioural changes occur.


9. Clinical Considerations

Advisories

  • Safe for long-term daily use
  • Pairs well with:
  • JointReflexa or JSTTonic for joint structural support
  • MetaTonic for metabolic hoof inflammation
  • EyeTonic for ocular microvascular-inflammation patterns
  • Ensure adequate hydration and forage

Contraindications

  • Pregnancy or lactation
  • Competitive horses under salicylate restrictions
  • Horses with known salicylate sensitivity
  • Use caution with anticoagulant medications


10. Supporting Products

  • TriBute — acute discomfort / flare-up support
  • JointReflexa — joint structural and connective tissue support
  • MetaTonic — metabolic inflammation axis
  • LKLCARE — liver–kidney–lymph detox pathways
  • BiomeTonic — gut comfort, microbial steadiness in pain-linked stress patterns


11. Standard Professional Disclaimer

DuoBute is a botanical nutritional supplement and not veterinary medicine. It does not diagnose, treat, or cure disease. Veterinary consultation is recommended when horses present with acute pain, are on concurrent medications, or are competing under controlled-substance rules.