LeakyGutCOMBO Veterinary Reference Extract

EquiNatural® | Botanical Nutritional Support for Hindgut Permeability, Faecal Water Patterns & Chronic Dysbiosis

Organically grown • Human grade • Not veterinary medicine

1. Important Context for Veterinary Review

Hindgut permeability — colloquially “leaky gut” — represents the end-stage consequence of long-standing dysbiosis, where inflammatory microbial pressure compromises the epithelial barrier and fluid escapes through the mucosa before and after defecation.

Key pathogenic contributors include:

• chronic SIBO-type microbial overgrowth (bacteria + archaea)
• volatile fatty acid imbalance and excessive fermentation
• epithelial irritation → tight-junction disruption
• mucosal depletion following prolonged inflammatory exposure
• immune hyper-reactivity in the intestinal wall
• stress-linked dysmotility and microbial shifts

Clinical signs may include:

• persistent faecal water pre/post defecation
• fluctuating dung consistency despite dietary stability
• abdominal or right-hind tension patterns
• gassy fermentation odour, bloating, or sensitivity to grooming
• on–off low-grade abdominal discomfort
• post-antibiotic biome instability
• permeability that persists even after baseline microbial intervention

LeakyGutCOMBO is not a symptomatic “plug-the-leak” product. It is structured to address microbial terrain, epithelial nourishment, and immune steadiness in the correct physiological order. Veterinary oversight is recommended with anticoagulants, corticosteroids, immune-suppressants, or prescribed GI medication.

Functional Positioning - LeakyGutCOMBO

LeakyGutCOMBO sits in the mid-stage of EquiNatural’s hindgut-support pathway: SiboCARE → LeakyGutCOMBO → KPUCOMBO

Where:

• SiboCARE targets dysbiosis and microbial imbalance.
• LeakyGutCOMBO addresses permeability, faecal water patterns, and mucosal compromise that persist after biome correction.
• KPUCOMBO is indicated when gut permeability co-exists with systemic toxin load, skin reactions, or metabolic strain (KPU-type patterns).

LeakyGutCOMBO is intended to:

• stabilise microbial overgrowth and reduce fermentative pressure
• nourish and reinforce the epithelial lining
• support immune modulation in the gut wall
• reduce fluid escape associated with hindgut permeability
• support the return of normal droppings consistency
• rebuild resilience in horses whose gut has “lost its ability to self-stabilise”

It is not designed for early-stage dysbiosis (use SiboCARE) or toxin-driven systemic dysfunction (consider KPUCOMBO).

Core Actions

• Supports microbial terrain recalibration in chronic dysbiosis
• Nourishes enterocytes and supports tight-junction integrity
• Encourages mucosal repair and epithelial replenishment
• Helps reduce hindgut fluid leakage associated with permeability
• Supports immune steadiness during repair
• Buffers oxidative stress during recovery
• Promotes more consistent droppings formation over time

2. Product Summary

LeakyGutCOMBO is a three-layer, functional herbal–nutritional system combining:

• SiboCARE (microbial modulation)
• GutAminos (mucosal repair nutrients)
• Organic Spirulina (immune and antioxidant support)

It is formulated for horses exhibiting:

• persistent faecal water
• intestinal permeability that did not resolve with microbial-level interventions alone
• biome instability following antibiotic use
• low-grade abdominal tension associated with dysbiosis and mucosal compromise

It is not intended for acute abdominal pain, febrile states, or gastric ulcer management.

3. Clinical Rationale (Nutritional Mechanisms of Action)

1. Microbial Terrain Stabilisation

(SiboCARE foundation)

Andrographis, Berberis, Oregano, Tabebuia, Smilax, Astragalus

• support microbial balance in chronic dysbiosis
• modulate bacteria + archaeal populations contributing to fermentation excess
• help reduce inflammatory metabolic signalling in the hindgut
• stabilise the terrain required for effective mucosal repair

2. Mucosal Repair & Epithelial Nourishment

(GutAminos support)

L-Glutamine, N-Acetyl L-Cysteine, Symphytum, Althaea, Plantago

• nourish enterocytes and support epithelial turnover
• encourage mucosal regeneration and resilience
• help maintain tight-junction integrity
• support reduction of fluid leakage

3. Immune Modulation & Antioxidant Buffering

(Spirulina integration)

Arthrospira (Spirulina)

• supports balanced immune-tone in the intestinal wall
• helps dampen chronic low-grade inflammatory drive
• contributes antioxidant protection during recovery
• supports long-term gut resilience and relapse prevention

LeakyGutCOMBO does not diagnose, treat, or prevent disease.  It provides nutritional support for the physiological processes underpinning hindgut integrity.

4. Nutritional Indications (Non-Diagnostic)

May be considered nutritionally in horses showing:

• faecal water patterns (pre- or post-defecation)
• droppings that fail to form despite dietary stability
• microbial instability post-antibiotics
• persistent permeability after completing SiboCARE
• abdominal or right-hind tension linked to hindgut sensitivity
• fluctuating manure consistency with fermentative odour
• chronic dysbiosis associated with stress or seasonal change

Not intended for:

• acute abdominal pain, colic-type symptoms
• active gastric ulcers (consider UlsaTonic / UlsaCOMBO)
• dysbiosis without permeability (use SiboCARE first)
• raw mucosa requiring slower introduction of SiboCARE + GutAminos separately

5. Composition

Combined Herbal–Nutritional Blend

A three-in-one formulation comprising EquiNatural’s SiboCARE, GutAminos and Organic Spirulina:

Botanical Components
Andrographis paniculata
Astragalus membranaceus
Berberis vulgaris
Symphytum officinale
Filipendula ulmaria
Origanum vulgare
Tabebuia impetiginosus
Plantago ovata
Smilax ornata
Althaea officinalis radix

Nutritional Compounds
L-Glutamine
N-Acetyl L-Cysteine
Arthrospira platensis (Spirulina)

Botanical safety note: Contains natural bitter, antimicrobial-type, and mucosal-supportive herbs. Gradual introduction is recommended.

6. Herb & Compound Micro-Monographs (Technical)

Andrographis paniculata
Bitter herb supporting microbial balance and hindgut terrain stability.

Astragalus membranaceus
Nutritional immunomodulator supporting repair-phase resilience.

Berberis vulgaris
Berberine-rich botanical assisting microbial modulation in dysbiotic states.

Symphytum officinale (Comfrey leaf)
Traditional mucilage-containing herb for epithelial nourishment.

Filipendula ulmaria (Meadowsweet)
Soothing herb supporting mucosal comfort and digestive steadiness.

Origanum vulgare
Potent botanical assisting rebalancing of microbial overgrowth.

Tabebuia impetiginosus (Pau d’Arco)
Traditional herb supporting microbial terrain modulation.

Plantago ovata (Psyllium husk)
Soluble fibre supporting stool formation and mucosal environment.

Smilax ornata (Sarsaparilla)
Traditional botanical supporting microbial and immune balance.

Althaea officinalis radix (Marshmallow root)
Rich mucilage source supporting mucosal hydration and soothing.

L-Glutamine
Primary enterocyte fuel supporting epithelial regeneration.

N-Acetyl L-Cysteine (NAC)
Nutritional precursor supporting antioxidant defence and mucosal integrity.

Arthrospira platensis (Spirulina)
Micronutrient-dense algae supporting balanced immune activity and repair.

7. Medication Considerations

Use under veterinary oversight when co-administered with:

• Corticosteroids or immune-suppressants
  → immune-modulating botanicals may influence systemic tone.
• Anticoagulants
  → certain herbs may have mild effects on vascular tone or platelet behaviour.
• Prescribed gastrointestinal medication or antibiotics
  → microbial-modulating botanicals may overlap with therapeutic aims.

No harmful interactions are known at nutritional levels; considerations relate to gut, immune, and microbial physiology.

8. Feeding Guidance

Daily Feeding Rate
12g per 100kg bodyweight (60g for a 500kg horse).
1 × 75ml scoop ≈ 40g.

Introduce gradually over 3–5 days due to bitter and antimicrobial-type botanicals.

Feed with quality ad-lib meadow hay to support biome restoration.

Fussy Eaters
Introduce slowly; mix with soaked fibre carriers.

Sensitivity Advisory
Reduce or discontinue if unexpected digestive or behavioural changes appear during microbial transition.

9. Clinical Considerations

Advisories

• Designed for chronic permeability, not simple biome imbalance.
• Minimum course: 1 month; longer use may be appropriate in persistent cases.
• Bitter and microbial-modulating herbs may transiently influence stool consistency as flora recalibrates.
• Combine with DuoBute for horses exhibiting discomfort during microbial transition.
• Stress-linked dysbiosis may benefit from concurrent StressTonic.
• Use with veterinary guidance if the horse is on prescribed GI, antibiotic, anti-inflammatory, or immune-related medications.

Contraindications

• Pregnant or lactating mares (due to hormonally active and detoxifying botanicals).
• Horses on anticoagulants, steroids, or immune-suppressants without veterinary oversight.
• Not for use during acute illness, febrile states, or colic-type presentations.

10. Supporting Products

• SiboCARE — first-line support for dysbiosis
• GutAminos — intensive mucosal repair where wall rawness is prominent
• KPUCOMBO — when systemic toxin burden accompanies permeability
• DuoBute — comfort support during repair phases
• StressTonic — for stress-related microbial instability
• VitaComplete / EquiVita — nutritional baseline during recovery

11. Standard Professional Disclaimer

LeakyGutCOMBO is a botanical, nutritional food supplement for horses. It is not veterinary medicine and does not diagnose, treat, or prevent disease.  Veterinary consultation is recommended for horses on concurrent medication or with diagnosed gastrointestinal or systemic conditions.