ULSACOMBO for Horses | Structured Support for Gastric Ulcers & Foregut Health
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~ Save 5% when purchasing as a COMBO vs individual products.
Reset your horse’s foregut health with EquiNatural's UlsaCOMBO - a complete, functional approach to persistent foregut comfort and recovery.
" Kero’s transformation is amazing - no more girthing tension, and he’s calm and super to ride. It still amazes me!"
Gastric ulcers are rarely just about stomach acid - when the ulcer cycle has become established, supporting just one piece of the puzzle is rarely enough.
Some horses seem stuck in a cycle - the girthiness improves, then returns; the tension settles, then flares again. One week they're comfortable and willing, the next they're grumpy, reactive, or suddenly difficult to tack up.
Often it's several pressures arriving at the same time - forage gaps, stress, discomfort, management changes, travel, box rest, even the stress created by the ulcer itself.
That's why UlsaCOMBO takes a wider view.
Rather than focusing on the stomach alone, it brings together four of our most widely used foregut support blends - DuoBute, StressTonic, UlsaTonic, and GutAminos - creating a complete programme designed to support comfort, emotional resilience, mucosal integrity, and the wider gastric environment.
*For the latest EGUS insights, see our main A-Z Condition/Ulcers
page in the Info Centre above.
Overview - why gastric ulcers keep returning
Gastric ulcers are almost always rooted in two things: feeding practices and stress.
Yet when people think about gastric ulcers, they think about stomach acid. And certainly, acid plays an unintentional role.
Unlike humans, a horse's stomach produces hydrochloric acid continuously, 24/7, whether food is present or not -- all perfectly normal for a trickle-feeding grazing animal relying on a constant supply of forage to buffer the stomach acid and allow it to do its job.
Thing is, when forage runs out and the stomach becomes empty, that unbuffered acid quickly begins to irritate the stomach lining.
For stabled horses this is especially challenging - long gaps between forage will leave parts of the stomach exposed to unbuffered acid for extended periods. Add in ridden work on an empty stomach, and over time this can contribute to the development of squamous ulcers - the type most commonly associated with acid splash.
But that's only half the story.
Some horses have excellent forage management yet still develop ulcer patterns. Research increasingly suggests that limited movement, boredom-driven behaviours (weaving, box-walking, wind-sucking, cribbing), or the daily emotional load of pain leads to glandular ( aka pyloric ) which are linked to stress physiology.
How? When a horse experiences ongoing physical or emotional stress, cortisol levels rise. While cortisol has an important short-term role, prolonged elevation affects digestion, and alters blood flow to the stomach lining, influencing the integrity of the mucosal lining, and can make normal repair processes much harder to maintain.
This helps explain why ulcer-prone horses often present with a much bigger picture than stomach discomfort alone. Owners frequently describe tension, behavioural changes, girthiness, irritability, poor performance, sensitivity around the ribs, and a horse who simply seems less comfortable in themselves.
By the time most owners arrive at UlsaCOMBO, they've usually realised they're not dealing with a simple acid problem - they're dealing with a cycle - one that involves pain, stress, mucosal irritation (the ulcer "wound"), and a foregut environment struggling to regain stability.
That's why UlsaCOMBO combines four complementary layers of support - helping address comfort, stress physiology, stomach lining integrity, and nutritional support for tissue renewal within one structured programme.
In short?
When ulcers involve more than stomach acid, recovery often requires more than stomach support alone.
How UlsaCOMBO fits into your horse's support plan
UlsaCOMBO is a good fit when your horse's foregut issues seem to involve more than one piece of the puzzle.
✔ Girthiness, tension, or sensitivity when tacking up
✔ Irritability, or changes in behaviour around the stable
✔ Signs commonly associated with gastric discomfort
✔ Stress-related digestive patterns during travel, stabling, competition, or management changes
✔ Horses coming off omeprazole or other PPIs
✔ A pattern that improves for a while, then seems to return
✔ You find yourself thinking, "there's more going on here than just stomach acid"
In short: if your horse appears to need support for comfort, stress, mucosal health, and recovery at the same time, UlsaCOMBO is where we start.
For many horses, UlsaCOMBO becomes the bridge between supporting one aspect of foregut health and supporting the whole gastric picture.
Rather than juggling multiple products individually, it brings together four complementary layers of support into one convenient blend.
From there, support can be adapted depending on what you're seeing.
- Supporting individual pieces of the picture
- UlsaTonic – where the primary focus is foregut comfort, acid buffering, and mucosal support.
- StressTonic – where stress, tension, anxiety, or emotional load appear to be driving the pattern.
- GutAminos – where additional nutritional support for tissue renewal and gut-lining integrity is required.
- DuoBute – where discomfort and inflammatory pressure are contributing to the cycle.
UlsaCOMBO brings these four approaches together when the boundaries between them are no longer so clear.
- Foundation support
Foregut resilience depends on more than targeted supplements alone. Consistent access to forage, appropriate management, and a forage-based mineral foundation such as VitaComplete or EquiVita help create the conditions that healthy digestion and normal mucosal maintenance depend upon.
*If you're not already feeding a mineral balancer, try one of our 1kg trial bags.
In summary
Use UlsaCOMBO when gastric stomach issues involve more than stomach acid alone. It brings together comfort support (DuoBute), emotional support (StressTonic), mucosal nourishment (GutAminos), and nutritional support for tissue renewal (UlsaTonic) into one structured programme, designed to help stabilise the foregut's rhythm again.
Composition & feed guide
UlsaCOMBO is a nutritional, functional food programme and not veterinary medicine. For more on this, see Dr Kellon's article - ' Nutrition is not 'Alternative' Therapy .
🌿Combined herbal blend
A combination of EquiNatural's DuoBute , StressTonic , UlsaTonic , & GutAminos , combined together as a convenient 4-in-1 food supplement.
Filipendula ulmaria, Salix Alba, Withania somnifera, Matricaria recutita, Eleutherococcus senticosus, Ginkgo biloba, Hydrocotyle asciatica, Melissa officinalis, Glycyrrhiza glabra, Urtica dioica Folia, Passiflora incarnata, Verbena officinalis, Symphytum officinale Folia, Althea officinalis Radix, Mentha piperita, Olea europaea, N-Acetyl L-Cysteine (NAC), L-Glutamine
Feed guide
Human grade, produced to ecological standards and free from agro-chemicals. See our Quality page for Organic Certification Documents.
- 15g/100kg bodyweight per day, i.e. 75g for a 500kg horse.
- 1 x level 75ml scoop = 18g
Fussy eater?
Horses sometimes have their own opinions (and strong tastebuds!), so now and then a new blend might need a little extra encouragement.
Check out our Fussy Eaters page, or send us a message - we've many helpful tips to make introducing new supplements easier.
♻️ Eco Note: Our packaging is recyclable and refillable.
Why choose UlsaCOMBO - the synergy behind the blend
UlsaCOMBO brings together four complementary layers of foregut support:
→ UlsaTonic for gastric comfort and mucosal support
→ StressTonic for stress resilience
→ DuoBute for comfort support
→ GutAminos for nutritional support of tissue renewal
Together they allow comfort, protection, resilience, and renewal to be supported simultaneously.
Functional intent
UlsaCOMBO is designed to support:
- gastric comfort and stomach resilience
- healthy mucosal protection and renewal
- stress-related influences on digestive health
- nutritional support for gut-lining maintenance
- long-term foregut stability
The goal is to help create the conditions that allow the wider foregut system to become calmer and more resilient over time.
Functional categories – foregut support in action
- Gastric protection & mucosal support - U
lsaTonic foundation
- Supporting the stomach's natural protective mechanisms and helping maintain a comfortable gastric environment. - Stress & emotional resilience - StressTonic foundation
- Supporting the body's response to physical and emotional stressors that can influence digestive function and gastric wellbeing. - Comfort & inflammatory balance - DuoBute foundation
- Helping maintain comfort and ease within the body, particularly where discomfort may be contributing to the wider cycle. - Nutritional support for tissue renewal - GutAminos foundation
- Providing targeted nutritional support for the cells involved in maintaining and renewing the gut lining. - Integrated foregut resilience - UlsaTonic + StressTonic + DuoBute + GutAminos
- Working together to support the wider factors that influence long-term foregut health, helping protection, comfort, and recovery occur side by side.
Big picture
The horses that struggle most with gastric issues are rarely dealing with stomach acid alone - they're often managing a combination of discomfort, stress, management pressures, and a stomach that has become increasingly reactive over time.
That's where UlsaCOMBO fits.
Its role is to bring together the key layers of support that many foregut horses need simultaneously.
Put simply, resilient stomachs depend on more than acid control alone.
Long term support after UlsaCOMBO
Once the foregut feels more settled, the focus shifts towards maintaining the conditions that helped it get there.
For most horses, that means:
- plenty of forage via quality hay , ensuring the stomach is never empty
- consistent turnout and movement
- a forage-balanced mineral foundation - EquiVita/VitaComplete – to help cover nutritional foundations.
- minimising unnecessary stress and forage gaps
In short, the goal becomes maintaining stability rather than constantly firefighting flare-ups.
Clinical considerations
UlsaCOMBO is a safe, functional nutritional support for deeper equine gastric comfort and foregut resilience. It can be fed short- or long-term, provided pregnancy, steroid, and anticoagulant cautions are observed.
Advisories
- Contains a blend of soothing, buffering, and adaptogenic botanicals traditionally used to support the stomach lining, digestive comfort, and stress resilience.
- Introduce gradually over 5–7 days to allow the digestive system to adjust to the new phytonutrient profile.
- Ensure constant access to forage , particularly during periods of rest, travel, or confinement, to maintain natural buffering of stomach acid.
- May be safely used alongside most veterinary medications; however, if your horse is currently prescribed omeprazole, sucralfate, or other antacid therapy, allow a few hours’ gap between feeds to avoid binding or absorption interference.
Contraindications
- Not suitable for pregnant or nursing mares due to inclusion of hormonally active and adaptogenic herbs (e.g. Withania somnifera , Passiflora incarnata ).
- Avoid use in horses on steroid, sedative, or anticoagulant medication without veterinary guidance, as herbs such as Liquorice Root and Nettle may potentiate their effects.
- Caution in horses with liver dysfunction or fluid retention, due to the natural glycyrrhizin content of Liquorice Root ( Glycyrrhiza glabra ).
- Competition horses: check FEI regulations if using blends containing Filipendula ulmaria , Salix alba , and Passiflora incarnata (controlled substances under competition rules).
Veterinary reference / formulary extract
A concise, vet-friendly reference is available for sharing with your vet.
FAQs for deeper gastric ulcer issues
What are the signs of gastric ulcers in horses?
The challenge with gastric ulcers is that there isn't one single symptom that definitively points to ulcers.
Instead, owners often notice a collection of subtle changes that seem to come and go over time.
Common signs include:
- Girthiness or sensitivity when tacking up
- Changes in behaviour or temperament
- Irritability, grumpiness, or becoming less tolerant than usual
- Resistance under saddle or reduced performance
- Sensitivity around the ribs, flanks, or abdomen
- Fussy eating (because it hurts to eat) or changes in appetite
- Stress-related behaviours such as weaving, cribbing, or box walking
- Recurring digestive sensitivity
Many owners describe a horse who simply seems less comfortable in themselves.
It's also important to remember that these signs are not unique to gastric ulcers and can occur with a range of other health issues. However, when several of these patterns appear together, particularly alongside known risk factors such as forage gaps, stress, travel, confinement, competition, or management changes, ulcers often become part of the conversation.
This is one reason we encourage owners to look beyond stomach acid alone and consider the wider factors that influence foregut health and resilience.
W hat is UlsaCOMBO designed to support?
UlsaCOMBO is designed for horses where foregut issues appear to involve more than stomach acid alone.
It brings together alleviation support for comfort and stress, alongside mucosal protection and tissue renewal, all into one structured programme helping support the wider factors that contribute to long-term gastric stability.
What's the difference between UlsaCOMBO and UlsaTonic?
UlsaTonic focuses specifically on supporting the stomach and its natural protective mechanisms.
UlsaCOMBO contains UlsaTonic but also includes DuoBute, StressTonic, and GutAminos.
In simple terms:
- UlsaTonic supports the stomach.
- UlsaCOMBO supports the wider ulcer cycle.
Why do gastric ulcers keep coming back?
This is one of the most common questions we hear.
By the time ulcers become a recurring pattern, there is often more involved than stomach acid alone.
Stress, pain, forage management, routine changes, confinement, travel, and the effects of the ulcer cycle itself can all contribute.
If only one part of the picture is addressed, symptoms may only improve temporarily before returning again.
The goal is not simply to support stomach acid balance, but to support the wider environment that allows the stomach to remain resilient.
My horse has confirmed ulcers. Is UlsaCOMBO a good place to start?
Many owners choose UlsaCOMBO when ulcers appear to be part of a bigger picture involving stress, behavioural changes, discomfort, or recurring gastric sensitivity.
Because it combines several complementary layers of support, it is often chosen where a broader approach is preferred.
What's included in UlsaCOMBO?
UlsaCOMBO combines four of EquiNatural's most widely used foregut support blends:
- UlsaTonic
- StressTonic
- DuoBute
- GutAminos
Together, they provide support for gastric comfort, emotional resilience, tissue renewal, and foregut stability.
Why is StressTonic included?
Research increasingly suggests that stress plays a significant role in many ulcer patterns, particularly glandular ulcers.
StressTonic is included to support emotional resilience and help address one of the most commonly overlooked influences on gastric health.
Why is GutAminos included?
The stomach and digestive tract rely on continual tissue renewal.
GutAminos provides targeted nutritional support for the cells involved in maintaining and renewing the gut lining, helping complement the other layers of the programme.
Can UlsaCOMBO be fed alongside omeprazole?
Many owners choose to use UlsaCOMBO alongside veterinary-led management programmes.
If your horse is currently receiving omeprazole, sucralfate, or other gastric medications, we recommend leaving a few hours between feeds and discussing supplementation with your vet.
Is UlsaCOMBO suitable for horses coming off omeprazole?
Yes. In fact, we recommend it.
Many owners introduce UlsaCOMBO during or after the transition away from omeprazole as part of a wider programme supporting gastric comfort, mucosal resilience, and long-term foregut stability.
What's the difference between squamous and glandular ulcers?
Squamous ulcers typically occur in the upper portion of the stomach and are most closely associated with forage gaps creating acid splash.
Glandular ulcers occur in the lower portion of the stomach and have a stronger connection to stress physiology, pain, inflammation, and disruption of the stomach's natural mucosal protection.
Many horses present with a combination of both.
My horse always has access to hay. Can ulcers still be an issue?
Surprisingly, yes.
Whilst forage availability remains one of the most important aspects of gastric management, some horses continue to show ulcer patterns despite ad lib hay availability.
Stress, pain, travel, confinement, illness, herd pressures, and management changes can all influence gastric health and the stomach's ability to maintain its natural protective mechanisms.
How long should I feed UlsaCOMBO?
We recommend feeding UlsaCOMBO for a minimum of 4-weeks, although longer-standing patterns may benefit from a longer course.
Can UlsaCOMBO be fed long term?
Yes. Many owners use UlsaCOMBO as a longer-term support programme where recurring gastric challenges are part of the horse's history.
However, we always encourage attention to forage management, movement, stress reduction, and lifestyle factors that influence gastric health.
What should my horse eat while on UlsaCOMBO?
For best results, we recommend a forage-first approach with constant access to quality forage wherever possible.
A forage-balanced mineral solution such as VitaComplete or EquiVita can aso help provide the nutritional foundations that healthy digestion and tissue maintenance depend upon.
How quickly will I notice a difference?
Every horse is different. Some owners report changes within the first week or so, whilst others notice a more gradual improvement as the different layers of support begin working together.
What should I do after finishing UlsaCOMBO?
Many owners move into a maintenance phase focused on good forage management, mineral balancing, and supporting long-term gut resilience.
Products such as BiomeTonic, WildFed, and VitaComplete or EquiVita (our two forage-balanced mineral foundation blends) are often used as part of a wider strategy to help maintain the progress made during the programme.
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