KPUCOMBO Organic Herbal Blend for Horses *A 5-in-1 solution for the KPU gut disorder, as one comprehensive blend
✨Smart Shopping When You COMBO! Pay 5% less than individual prices
Tackle the complexities of KPU (Cryptopyrroluria) with KPUCOMBO, an effective, stabilising, 5-in-1 blend combining EquiNatural's SiboCARE , GutAminos , P5P , B12-Balance & organic Spirulina.
With customers continually reporting transformative results with KPUCOMBO, this synergistic formula stabilises the hindgut, reconnects the gut:liver pathway, and supports detoxification for long-term health and wellbeing.
✨ “My horse is transformed - faecal water gone, energy up, and coat shining!”
Note:
If your horse needs more intensive rehabilitation after long-term or severe KPU, see our full 2-month, structured 3-stage KPU Reset Programme for the complete KPU detoxification protocol, and immune recalibration support.
Overview
What is KPU?
Cryptopyrroluria (KPU) is a relatively recently identified, yet widespread, multi-metabolic detoxification disorder, often referred to as "the disease with a thousand faces" due to its extensive range of symptoms.
These can include persistent gut issues, skin and hoof problems, musculoskeletal challenges, unexplained swelling, and more.
At its root, KPU stems from a disrupted hindgut microbiome, very often starting from birth (based on how the foal was raised), leading to a deficiency in the hindgut's natural production of Pyridoxal-5-Phosphate (P5P), the activated
form of vitamin B6. This deficiency impairs the liver's detoxification process, allowing toxins to accumulate and disrupt overall health.
How KPUCOMBO helps
KPUCOMBO provides targeted support to rebalance the hindgut microbiome, restore the gut-liver pathway, and enhance the body's natural detoxification processes.
For the latest KPU updates, see our main A-Z Equine Condition/KPU page in the Advice Centre above.
Is KPUCOMBO Right for My Horse?
🌿 Ideal for horses who...
- Show multiple, persistent or recurring issues - from gut sensitivity, loose droppings or faecal water, to poor coat or hoof quality.
- Have a long history of unexplained metabolic, skin, or musculoskeletal problems that don’t resolve with standard gut or liver support.
- Display signs of chronic detoxification stress - dull coat, weight fluctuations, puffy eyes or limbs, or chemical/environmental sensitivities.
- Have previously been on repeated antibiotic, wormer, or steroid courses and need hindgut stabilisation and liver pathway repair.
- Are ready for a deeper stage-two level of gut support, beyond SiboCARE or LeakyGutCOMBO.
⚠️ Not suitable for horses who...
- Are pregnant or nursing mares (contains hormonally active botanicals).
- Are on steroid, immune-suppressant, or anticoagulant medication without veterinary oversight.
- Are currently in acute digestive distress or active inflammation — start with SiboCARE first to clear dysbiosis before moving on to KPUCOMBO.
Need to COMPARE our gut system blends?
Helping you choose the right support for your horse's gut support:
SiboCARE 🆚 LeakyGutCOMBO 🆚 KPUCOMBO
Composition & Feed Guide
KPUCOMBO is a nutritional, functional food supplement and not veterinary medicine. For more on this, see to Dr Kellon's Horse Sense - Nutrition is not 'Alternative' Therapy .
🌿Combined Herbal Blend
A combination of EquiNatural's SiboCARE , GutAminos , P5P (Activated B6), B12-Balance & organic Spirulina , combined together as one convenient feed supplement.
Andrographis paniculata, Astragalus membranaceus, Berberis vulgaris, Symphytum officinale, Filipendula ulmaria, Origanum vulgare, Handroanthus impetiginosus, Plantago ovata, Smilax ornata, L-Glutamine, N-Acetyl L-Cysteine, Althaea officinalis Radix, Pyridoxal-5-Phosphate (P5P),
Fucus vesiculosus, Symphytum officinale Folia, Taraxacum officinalis Folia, Crataegus oxycanthoides, Hericium erinaceus, & Lentinula edodes, Arthrospira platensis
Feed Guide
Human-grade, produced to ecological standards and free from agro-chemicals. See our Quality page for Organic Certification Documents.
- 13g/100kg bodyweight per day, i.e. 66g for a 500kg horse.
- 1 x level 75ml scoop = 40-grams.
Fussy Eater?
Horses may have their own opinions (and strong tastebuds!), so now and then a new blend might need a little extra encouragement. This doesn’t reflect the quality or efficacy of the product, but rather their natural instinct towards new.
- Check out our Fussy Eaters page, or send us a message - we've many helpful tips to make introducing new supplements easier.
Footnotes
- Each item is available separately in our KPU Shop page.
- Laboratory tested for identification and compliance to the British and European Pharmacopoeia standards.
- Human grade.
- ♻️ Eco Note: Our packaging is recyclable and refillable.
- 🧊 Storage Tip: Keep cool and dry.
Clinical Considerations
Advisories
- KPUCOMBO provides deep functional support across the gut–liver–immune axis. Introduce gradually over 3–5 days, particularly for sensitive horses.
- For horses previously showing signs of discomfort or stress, support alongside DuoBute(for gut comfort) or StressTonic(for adrenal-calming support).
- Once the KPUCOMBO course has finished and you're happy that the gut has stabilised, follow with a 1-month course of LKLCARE for 4–6 weeks to help tone and clear the detoxification organs (liver, kidneys, lymph).
- Ensure 24/7 access to quality meadow hay and natural movement to maintain hindgut motility and microbial balance.
- Contributes as part of the full KPU Reset Programme for horses requiring deeper metabolic recovery.
Contraindications
- Not suitable for pregnant or lactating mares(contains hormonally active botanicals).
- Use caution in horses receiving steroid, immune-suppressant, or anticoagulant medications; veterinary guidance is recommended.
- Not recommended during autoimmune flare-ups or late-stage Lyme, where immune stimulation may be undesirable. Always stabilise first.
© EquiNatural 2025. All content is original work protected under copyright, and may not be re-published, duplicated, or rewritten for commercial use without permission.
