P5P Activated Vit.B6 (Pyridoxal-5-Phosphate) *Nutrient for horses - essential for liver detoxification in the KPU horse
⚠️ P5P is designed to be used as part of a wider protocol. For best outcomes, please see our KPU/Hindgut Reset Programme guides, as r esults may not be seen if used in isolation.
When a horse has ongoing hindgut dysbiosis - often seen alongside leaky gut/faecal water - it means certain vital nutrients are no longer being naturally produced.
One of these is P5P (Pyridoxal-5-phosphate) – the natural, ‘activated’, bioavailable form of vitamin B6 – a key co-factor involved in metabolic and immune function.
P5P plays an essential role in liver metabolism, neurotransmitter synthesis, and energy pathways. When hindgut disruption interferes with its natural production, this leaves a functional gap that the body still depends on.
Here’s why that matters
Picture a 4x4 vehicle and your horse’s trailer. Without a towbar , your trailer’s going nowhere.
Now picture the liver as the 4x4, and everything your horse consumes – nutrients, by-products, environmental toxins – as the trailer. Before these can be used or safely cleared, they must be processed by the liver.
P5P – this small but vital nutrient – acts as the liver’s ‘towbar’. Without it, the liver cannot efficiently convert substances into usable forms or prepare them for safe elimination.
Under normal circumstances, a healthy hindgut contributes to the natural production of P5P. But when hindgut function is compromised – as in dysbiosis – this process is disrupted, creating a knock-on effect across metabolism.
✨ “Within days of starting B6, I saw a massive change in him – it was astounding.”
📦 SUBSCRIBE & SAVE 10% ON P5P
For more information on KPU/Hindgut Dysbiosis, an
d the importance of P5P, see our A-Z Equine Condition/KPU page
.
Overview
A healthy hindgut biome plays a vital role in equine health, producing essential metabolites (postbiotics) that the horse cannot obtain from food. Among these are two crucial B vitamins, required in their activated forms for proper metabolic function:
- B6 as Pyridoxal-5-Phosphate (P5P) – the only form recognised and utilised by the equine liver.
- B12 as Methylcobalamin – to complement your horse's natural B12 balance alongside P5P. (See our organic plant-sourced B12-Balance supplement for a complete solution.)
Unlike their synthetic counterparts (such as pyridoxine for B6), these activated forms are fully bioavailable - whereas synthetics are treated as toxins and simply excreted.
Why P5P matters
Pyridoxal-5-Phosphate (P5P) is the liver’s preferred, bioavailable form of B6, essential for metabolising toxins and maintaining overall metabolic health.
In horses with hindgut dysbiosis - a condition linked to leaky gut, faecal water syndrome, and chronic inflammation - the natural production of P5P is disrupted, triggering a cascade of metabolic disorders.
By supplementing with P5P, you provide critical support for:
~ Liver detoxification
Without P5P, the liver cannot efficiently process and eliminate toxins.
~ Gut & immune health
Supports a balanced gut biome and healthy immune response.
~ Neurotransmitter synthesis
Essential for the production of serotonin, dopamine, and GABA, supporting mental and emotional well-being.
~ Cellular function
P5P is vital for synthesising amino acids, neurotransmitters, sphingolipids, and aminolevulinic acid, all of which are key to cellular health and overall functionality.
The role of the hindgut microbes
The beneficial microbes in the hindgut biome ferment forage fibre, producing metabolites (postbiotics) essential for health, including:
- Vitamin B6 ( Pyridoxal-5-Phosphate ) – Supports detoxification, metabolism, and neurological health.
- Vitamin B12 ( Methylcobalamin ) – Crucial for red blood cell formation, nerve function, and energy production.
These activated forms are recognised and utilised by the liver, unlike synthetic versions, which are simply treated as toxins and excreted as waste.
For a holistic approach to metabolic health, P5P works synergistically with our B12-Balance supplement, offering a complete solution to support your horse’s natural balance.
Composition & Feed Guide
Composition
100% pure Pyridoxal-5-Phosphate (P5P) - activated Vitamin-B6.
Feed
- 1g/day
- Scoop included - 1-level 2.5ml scoop = 1g
- Supplied in a resealable, food-grade foil pouch for freshness.
- Origin China.
Important Note
Footnotes
- Human Grade.
- UK Certificate of Analysis & Quality Control available on request.
- ♻️ Eco Note: Our packaging is recyclable and refillable.
- 🧊 Storage Tip: Keep cool and dry.
Clinical Considerations
P5P is the active form of vitamin B6, a water-soluble nutrient involved in amino acid metabolism, neurotransmitter production, and overall metabolic function.
P5P is generally very well tolerated by horses when fed at the recommended feeding levels. There are no meaningful equine-specific contraindications at normal doses, the only “true” caution in wider literature being very high chronic dosing → neurological effects- but this is extreme and not relevant when fed correctly.
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