KPUCOMBO🍃MAY SALE - 20%-OFF *Organic Herbal Blend for Horses - structured nutritional support for the KPU spectrum

What is KPU?

Cryptopyrroluria (KPU) is a complex metabolic pattern increasingly recognised in equine functional medicine. Now widespread, it's specifically seen as a multi-metabolic detoxification disorder, often referred to as " the disease with a thousand faces " due to its extensive range of symptoms.

Rather than presenting as one clear issue, horses on the KPU spectrum often show recurring, interconnected patterns involving the gut, skin, hooves, energy, immune system, and overall resilience.

At its root, KPU stems from a disrupted hindgut microbiome (very often starting from birth based on how the foal was raised), and impaired nutrient production of Pyridoxal-5-Phosphate (P5P), the activated form of vitamin B6.

Over time, this deficiency impairs the liver's detoxification process, allowing toxins to accumulate and disrupt overall health.

How KPUCOMBO helps

KPUCOMBO brings key elements together into one structured blend - targeting hindgut stability, the gut-liver pathway, nutrient activation, and re-establishing the internal "detoxification" housekeeping processes.

* If it’s one clear issue, stay targeted. If it’s multiple patterns that keep circling back, this is where we step in.

KPUCOMBO is a good fit when your horse has multiple, ongoing issues that never quite resolve – the kind that seem connected, but never fully explained.

✔ Multiple recurring patterns – gut, skin, hooves, respiration, i.e. pollen allergies, sweet itch, mallenders, ongoing cough, repeated abscessing... rather than just one isolated issue
✔ Droppings - loose, inconsistent, or include faecal water that keeps returning
✔ Coat quality - dull, patchy, or slow to improve, despite good feeding
✔ Hooves - weak, slow-growing, or prone to cracking or flare
✔ Your horse seems overly sensitive to feeds, environment, seasonal changes such as pollens, midges...
✔ A history of repeated interventions, with no lasting resolution
✔ You feel like you've tried everything but nothing works

In short: if your horse shows a pattern of recurring, interconnected issues that don’t fully resolve, KPUCOMBO is the deeper, whole-system blend designed to help bring everything back into balance.

How KPUCOMBO fits into your horse’s support plan

KPUCOMBO is designed as a whole-system starting point for horses showing multiple, interconnected patterns – where addressing one issue at a time hasn’t led to lasting resolution.

Rather than layering several individual products, KPUCOMBO brings key elements together into one structured blend – supporting the hindgut, reconnecting the gut–liver pathway, and providing targeted nutritional support where it’s often most needed.

In many cases, KPUCOMBO is used as a standalone course, allowing the system to stabilise and rebalance before making further adjustments.

From there, support can be adapted depending on how your horse responds:

• DuoBute – additional gut comfort during the early stages.
• StressTonic – where tension, sensitivity, or adrenal load are part of the picture.

• LKLCARE – often introduced afterwards to support the liver–kidney–lymph axis.
• For more complex or long-standing cases, KPUCOMBO also forms part of our structured KPU Reset Programme , offering a step-by-step approach to deeper metabolic support.

In short

Use KPUCOMBO when multiple patterns keep circling back – and allow the system time to stabilise before layering further support.

KPUCOMBO is a nutritional, functional food supplement and not veterinary medicine. For more on this, see to Dr Kellon's Horse Sense - Nutrition is not 'Alternative' Therapy .

🌿Combined herbal blend

A combination of EquiNatural's SiboCARE , GutAminos , P5P (Activated B6), B12-Balance & organic Spirulina , combined into one structured nutritional blend.

Andrographis paniculata, Astragalus membranaceus, Berberis vulgaris, Symphytum officinale, Filipendula ulmaria, Origanum vulgare, Handroanthus impetiginosus, Plantago ovata, Smilax ornata, L-Glutamine, N-Acetyl L-Cysteine, Althaea officinalis Radix, Pyridoxal-5-Phosphate (P5P), Fucus vesiculosus, Symphytum officinale Folia, Taraxacum officinalis Folia, Crataegus oxycanthoides, Hericium erinaceus, & Lentinula edodes, Arthrospira platensis

Feed guide

Human-grade, produced to ecological standards and free from agro-chemicals. See our Quality page for Organic Certification Documents.

• 13g/100kg bodyweight per day, i.e. 66g for a 500kg horse.
• 1 x level 75ml scoop = 40-grams.

Energetic architecture explains how the components within KPUCOMBO are structured to support whole-system recalibration across the gut–liver–immune axis.

KPU patterns rarely exist in isolation. The hindgut, nutrient pathways, liver processing, and immune resilience all influence each other – and when communication between those systems breaks down, recurring multi-system patterns can emerge.

KPUCOMBO is designed to support five interconnected pathways:

→ Hindgut stability
→ Gut lining integrity
→ Nutrient activation
→ Hepatic processing
→ Immune & metabolic resilience

Functional categories – KPU support in action

1. Hindgut stabilisation & microbial balance - Andrographis paniculata, Berberis vulgaris, Handroanthus impetiginosus, Astragalus membranaceus, Filipendula ulmaria, Plantago ovata, Smilax ornata
   Re-establishing a stable gut environment where beneficial microbes can function effectively and metabolic disruption is reduced.
2. Gut lining repair & nutrient absorption - L-Glutamine, Althaea officinalis radix, Symphytum officinale
   Supporting the integrity of the intestinal wall to allow proper absorption of nutrients essential for metabolic function.
3. Nutrient activation & biochemical support - Pyridoxal-5-Phosphate (P5P), Vitamin B12 (B12-Balance), N-Acetyl L-Cysteine
   Restoring key nutrient pathways often compromised in KPU, particularly those involved in detoxification and enzyme function.
4. Hepatic processing & detoxification support - Taraxacum officinale folia, Crataegus oxyacanthoides, Arthrospira platensis (Spirulina)
   Supporting the liver’s ability to process metabolic by-products and maintain internal balance.
5. Immune modulation & systemic resilience - Astragalus membranaceus, Hericium erinaceus, Lentinula edodes
   Helping stabilise immune responses and support overall metabolic resilience as the system recalibrates.

This layered approach allows the system to stabilise gradually and regain steadier internal balance over time.

Advisories

• For horses previously showing signs of discomfort or stress, support alongside DuoBute(for gut comfort) or StressTonic(for adrenal-calming support). *See "Your support plan - is KPUCOMBO right for your horse?" tab above.
• Once the KPUCOMBO course has finished and you're happy that the gut has stabilised, follow with a 1-month course of LKLCARE for 4–6 weeks to help support the liver–kidney–lymph axis and maintain internal balance.
• Ensure 24/7 access to quality meadow hay and natural movement to maintain hindgut motility and microbial balance.
• Contributes as part of the full KPU Reset Programme for horses requiring deeper metabolic recovery.

Contraindications

• Not suitable for pregnant or lactating mares(contains hormonally active botanicals).
• Use caution in horses receiving steroid, immune-suppressant, or anticoagulant medications; veterinary guidance is recommended.
• Not recommended during autoimmune flare-ups or late-stage Lyme, where immune stimulation may be undesirable. Always stabilise first.