METACOMBO *Organic Herbal Blend for Horses - a comprehensive 3-in-1 nutritional support for the permanently hangry horse / stubborn crest (aka leptin resistance)
🎁Smart Shopping When You COMBO! Pay 5% less than individual prices
MetaCOMBO is the ultimate 3-in-1 solution for the EMS horse, combining the powerful benefits of EquiNatural's DuoBute , MetaTonic , and Acetyl L-Carnitine into one comprehensive blend.
Formulated to support metabolic balance, manage inflammation, and fuel cellular energy, MetaCOMBO is the go-to supplement for horses facing the challenges of EMS/IR/Leptin Resistance and laminitis.
This is also the same combination that Carol, EquiNatural's founder, gave her own horse, connemara Murphy, who was diagnosed with IR aged 7 in 2001, and the inspiration behind MetaTonic. He reached the fantastic age of 31, and able to stay on grass 24/7.
✨ "My horse’s crest softened within weeks, and his energy is through the roof."
Overview
MetaCOMBO combines three of EquiNatural’s most trusted products to deliver comprehensive support:
- DuoBute : A synergistic blend of organic phytonutrients that assists the body’s natural inflammatory processes, promoting comfort and mobility.
- MetaTonic : A nutrient-rich herbal blend supporting metabolic balance, hindgut health, and hoof integrity, particularly for laminitis-prone horses.
- Acetyl L-Carnitine (Alcar): The ultimate cellular fuel, transporting fatty acids for energy production, supporting muscle function, and enhancing resilience in EMS/IR horses by playing a key role in reversing leptin resistance.
Together, these three products form a powerhouse blend addressing inflammation, metabolism, and energy - supporting your horse from the inside out.
Is MetaCOMBO Right for My Horse?
MetaCOMBO is designed for horses dealing with the combined metabolic patterns of EMS - inflammation, insulin resistance, and leptin resistance (solid crest)/fat pads. If your horse shows any of the signs below, MetaCOMBO is very likely the right fit.
🌿 Ideal for horses who…
- Have a firm, stubborn crest, or show clear signs of leptin resistance.
- Struggle with metabolic sensitivity during grass flushes - becoming footy, pottery, sluggish, or 'not quite right'.
- Show inflammation-linked discomfort, short strides, or intermittent reluctance to move.
- Experience digital pulse fluctuations, warm hooves, or sensitivity on uneven ground.
- Have had laminitis before and need more comprehensive, layered support (metabolic + inflammatory + cellular energy).
- Gain weight easily or stay “permanently hangry,” despite being on a careful low-NSC diet.
- Are stiff, tired, or lack stamina - often seen in EMS horses with low cellular energy.
- Struggle with fat pads, crest fat, or uneven weight distribution.
- Have already tried single-focus supplements but need something broader and more synergistic.
If your horse shows both metabolic signs + inflammation + crest tension or fatigue, MetaCOMBO provides the most targeted, all-in-one support.
⚠️ Not suitable for horses who…
- Are pregnant or nursing, due to hormonally active botanicals.
- Have salicylate sensitivity, bleeding disorders, or are on anticoagulant medication (contains Filipendula ulmaria & Salix alba ).
- Are experiencing an acute laminitic crisis(severe heat, immobility, or bounding pulses). Stabilise first, then introduce MetaCOMBO once comfortably walking for at least two weeks.
- Have significant liver compromise - use under veterinary supervision.
Which blend - MetaCOMBO or MetaTonic?
Each plays a distinct role in metabolic balance:
→ MetaCOMBO - The ultimate 3-in-1 support system for EMS horses, combining MetaTonic + Acetyl L-Carnitine + DuoBute into one comprehensive blend. Perfect for horses with inflammation + metabolic sensitivity + crest/neck tension/leptin resistance.
→ MetaTonic - Your foundational daily metabolic support. Ideal for EMS/IR horses needing help with crest firmness, circulation, hoof comfort, toxin load, and stable glucose–insulin rhythms.
If your horse is showing combined signs of sugar sensitivity, footiness, crest changes, or metabolically-linked inflammation, MetaCOMBO is the best place to start.
For many EMS horses, this combination is genuinely life-changing - just as it was for EquiNatural's Murphy.
Composition & Feed Guide
MetaCOMBO is a nutritional, functional food supplement and not veterinary medicine. For more on this, see Dr Kellon's article - Nutrition is not 'Alternative' Therapy
.
🌿Combined Herbal Blend
Human-grade, produced to ecological standards and free from agro-chemicals. See our Quality page for Organic Certification Documents.
A combinatio
n of EquiNatural's DuoBute
, MetaTonic
, & Acetyl L Carnitine
, combined together as a convenient 3-in-1 food supplement.
Berberis vulgaris, Galium aperine, Foeniculum vulgare, Galega officinalis*, Crataegus oxycanthoides
, Silybum marianum, Urtica dioca, Tabebuia impeteginosa, Smilax ornata, Acetyl L Carnitine, Filipendula ulmaria, & Salix alba
** Filipendula ulmaria & Salix alba contains Salicylic acid, a controlled substance, so always check competition rules.
Feed Guide
- 12g/100kg bodyweight per day, i.e. 60g for a 500kg horse.
- A level 75ml scoop = 14g.
Fussy Eater?
Horses may have their own opinions (and strong tastebuds!), so now and then a new blend might need a little extra encouragement. This doesn’t reflect the quality or efficacy of the product, but rather their natural instinct towards new flavours.
Check out our Fussy Eaters page, or send us a message - we've many helpful tips to make introducing new supplements easier.
Footnotes
- Each item is available separately in our EMS/IR Metabolic Horse Shop page.
- Laboratory tested for identification and compliance to the British and European Pharmacopoeia standards.
- Human grade.
- ♻️ Eco Note: Our packaging is recyclable and refillable.
- 🧊 Storage Tip: Keep cool and dry.
Clinical Considerations
MetaCOMBO is a functional nutritional blend formulated to support metabolic balance, comfort, and cellular energy in EMS/IR and laminitis-prone horses.
Advisories
- Think fortify - switch processed feeds to a grass forage-fibre feed, i.e a meadow cob/chaff.
- Quality meadow hay , fed 24/7, is going to be your saviour here, to help restore the beneficial hindgut microbiome.
- Close the nutrient gap with VitaComplete , our forage-balanced mineral supplement formulated for horses on a predominantly hay-diet.
- Contains natural salicylates ( Meadowsweet and Willow Bark ); exercise care if the horse is also receiving NSAIDs.
- Ensure constant access to low-sugar forage and avoid high-starch or molassed feeds while using MetaCOMBO.
Contraindications
- Not suitable for pregnant or nursing mares due to hormonally active botanicals.
- Avoid use in horses with salicylate sensitivity, bleeding disorders, or those receiving anticoagulant medication.
- Not advised for horses showing signs of acute laminitic crisis (severe heat, reluctance to move, bounding pulses). Always stabilise the horse first, where they've been walking comfortably for at least two weeks.
- Competition horses: Filipendula ulmaria and Salix alba contain salicylic acid, a controlled substance - always check up-to-date withdrawal rules.
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