KPUCOMBO *A 5-in-1 solution for the KPU gut disorder, as one comprehensive blend
Tackle the complexities of KPU (Cryptopyrroluria) with KPUCOMBO, a powerful 5-in-1 blend combining EquiNatural's SiboCARE , GutAminos , P5P , B12-Balance & organic Spirulina.
This synergistic formula stabilises the hindgut, reconnects the gut:liver pathway, and supports detoxification for long-term health and wellbeing.
✨ “My horse is transformed - faecal water gone, energy up, and coat shining!”
Need to COMPARE our Gut System blends?
Helping you choose the right support for your horse's gut support:
SiboCARE🆚LeakyGutCOMBO🆚KPUCOMBO
💡Top Tip
If your horse needs significantly more support, i.e. gut pain/inflammation and a detoxification system reset, see our full 2-month / 3-stage See our KPU RESET PROGRAMME for the complete KPU detoxification protocol, including proactive support suggestions thereafter.
📌 Note
Horses sometimes have their own opinions (and strong tastebuds!), so now and then a new blend might need a little extra encouragement. This doesn’t reflect the quality or efficacy of the product, but rather their natural instinct towards new flavours.
Check out our Fussy Eaters
page, or send us a message
- we've many helpful tips to make introducing new supplements easier.
Overview
What is KPU?
Cryptopyrroluria (KPU) is a relatively recently identified, yet widespread, multi-metabolic detoxification disorder, often referred to as "the disease with a thousand faces" due to its extensive range of symptoms.
These can include persistent gut issues, skin and hoof problems, musculoskeletal challenges, unexplained swelling, and more.
At its root, KPU stems from a disrupted hindgut microbiome, very often starting from birth (based on how the foal was raised), leading to a deficiency in the hindgut's natural production of Pyridoxal-5-Phosphate (P5P), the activated
form of vitamin B6. This deficiency impairs the liver's detoxification process, allowing toxins to accumulate and disrupt overall health.
How KPUCOMBO helps
KPUCOMBO provides targeted support to rebalance the hindgut microbiome, restore the gut-liver pathway, and enhance the body's natural detoxification processes.
For the latest KPU updates, see our main A-Z Equine Condition/KPU page in the Advice Centre above.
Composition & Feed Guide
KPUCOMBO is a nutritional, functional food supplement and not veterinary medicine. For more on this, see to Dr Kellon's Horse Sense - Nutrition is not 'Alternative' Therapy .
🌿Combined Herbal Blend
Human-grade, produced to ecological standards and free from agro-chemicals. See our Quality page for Organic Certification Documents.
A combination of EquiNatural's SiboCARE
, GutAminos
, P5P
(Activated B6), B12-Balance
& Spirulina
, combined together as one convenient feed supplement.
- 13g/100kg bodyweight per day, i.e. 66g for a 500kg horse.
- 1 x 15ml scoop = 9-grams.
- Want a scoop? You can add a scoop to your basket during checkout.
- See each product for individual compositions.
- 1-yr shelf life.
- Supplied in a resealable, food-grade foil pouch for freshness.
Footnotes
- Feed as a minimum 1-month course.
- For fussy eaters, start with a pinch and slowly build your way up.
- Pregnant or nursing mares - always seek veterinary advice before feeding.
- Each item is available separately in our KPU Shop page.
- ♻️ Eco Note: Our packaging is recyclable and refillable.
- 🧊 Storage Tip: Keep cool and dry.
Recommended
- If your horse is showing signs of discomfort or stress, alleviate with our our DuoBute / StressTonic.
- Following the KPUCOMBO, feed our LKLCARE to detox and tone the major detoxification organs - the liver, kidneys, and lymph nodes. Alternatively, see our KPU Reset Programme.
- Finally, quality meadow hay , fed 24/7, is going to be your saviour here to help restore the beneficial hindgut microbiome.
Client Feedback
Clients continually report transformative results with KPUCOMBO, highlighting improvements in faecal water, energy levels, coat condition, mobility, and overall wellbeing. Horses have shown rapid changes in behaviour, posture, and appetite, with some owners seeing results in just a few days.
Highlights include:
- Dramatic reductions in faecal water and improvements in gut health.
- Significant behavioural changes, including calmer demeanours and increased energy.
- Improvements in coat, hoof quality, and overall physical condition.
- Positive impacts on musculoskeletal health and mobility.
